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                                                                                                                                                    The Power of Nuclear Medicine           

The Best Diagnosis Device in Medical Field

 

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PET-CT Advantage

 

 

A Combination of two body-imaging techniques (PET and CT) can more accurately tell doctors how far a patient’s cancer has spread than full body MRI scans. As the Name implies, the PET, which is Positron Emission Tomography shows metabolism and the function of cells ( How cells are utilizing nutrients like sugar an oxygen) , where the CT which is Computed Tomography shows detailed anatomy structures, which allows doctors to see the internal structures within the human body.

This kind of combination of two machines will allow doctors to diagnose and localize smaller tumors early and make more informed treatment decisions for their patients. It also makes easy to differentiate normal from abnormal structure.

 PET/CT camera: www.nuclear medicine.standford.edu

 

 

 

1.     PET-CT on Head and Neck imaging

 

Combined PET-CT used in head and neck imaging leads to increase confidence in image interpretation, according to a study from Memorial Sloan- Kettering Cancer Center (MSKCC) in New York City. (SNM.org)

The study evaluated the clinical usefulness of PET-CT technology in 68 patients with head and neck cancer by comparing the PET images with PET-CT fusion images. Heiko Schoder, MD who is assistant attending physician at MSKCC and lead author of the Study said that they found that combined PET-CT more precisely defined the lesion’s anatomical location in 42 percent (65) of all lesions seen in the regular PET images. (SNM.org)

Dr. Schoder suggested that in the future, combined PET-CT would be the method of choice when PET is performed for staging and flow-up of patients with cancers in the head and the neck.

The University of Pittsburgh researchers have found the same idea that Dr. Schoder predicted earlier. The researchers believe that the combined PET-CT scanner is the most powerful imaging device available for localizing, evaluating and therapeutic monitoring of head and neck cancer. They also have found that it can be equally useful for other cancers that are difficult to pinpoint.

 (University of Pittsburgh Cancer Institute). 

  www.petscaninfo.com

 

 

2.     PET/CT on Osteomylitis PET-CT diagnosis

In a study headed by Dr. Zohar Keidar, MD, PHD, physician from Rambam Medical Center demonstrated that a single, non-invasive test using combined PET-CT imaging could effectively diagnose localized Osteomylitis adjacent to soft tissue infection in the diabetic foot. The team presented the findings of its study at the Society of Nuclear Medicine’s 51st Annual Meeting in Philadelphia last year (SNM.org).   

Diabetes can reduce circulation in the extremities. Poor circulation, combined with the reduced ability to fight off even minor infections, puts diabetics at risk for development of chronic bone infection.

For the study, the researchers evaluated patients with suspected osteomyelitis using PET-CT imaging and F-18 as a radioactivity. PET/CT identified osteomyelitis in five patients, non-bone infection in three and no infection in the remaining patients. (SNM)

 

3.     PET-CT on Ovarian Cancer   

Another advantage that PET-CT presents is the diagnosis of the Ovarian Cancer, which is malignant tumor of the ovary.  Ten PET and 33 PET-CT scans were performed on 28 patients with ovarian cancer suspected to have spread to the abdominal cavity. There were three true positive and 2 true negative results with PET alone and 14 true positive and 10 true negative with PET-CT. (Hopkins medicine). The PET scan produced two false positives, while PET-CT produced only one. There were no false negatives with PET alone, and PET-CT had five. Combined PET-CT had a high sensitivity rate, accurately diagnosing cancer 73.6% of the time, that is 14 out of 19, and PET alone was able to diagnose all three positive cancers.

 

4.     PET-CT on Lung Cancer

Recently, research from Germany conducted a clinical trial to compare the accuracy of the combined PET and CT scan, to either scan alone, for staging of patients who had been diagnosed with NSCLC. This trial involved 27 patients underwent a PET scan, a CT scan, and a PET-CT scan. Accurate staging was obtained in 26 of the 27 patients with the combined PET-CT, compared to only 20 with PET alone and 19 with CT alone.

Spread of Cancer to distant sites in the body (Metastasis) was found in 4 patients (17 Metastasis) on PET-CT, 4 patients (14 metastases) on CT alone, and 2 patents (4metastasis). After Reading obtained from PET-CT, treatment advised to patients would have been changed in 15 % of patients with results from PET alone and 19% of patients with result obtained from CT. (Radiology).

Researchers from Switzerland recently conducted a clinical trial to directly compare different staging methods in patients suspected of having NSCLC. This trail involved 49 patients who underwent CT and PET imaging. Experts interpreted results from CT scans alone, PET scans alone, Visual correlation of CT and PET scans and integrated PET-CT scans in each patients. Patients then underwent surgery and laboratory testing of removed tissue to determine a definitive diagnosis. Integrated PET-CT scans were superior compared to other imaging types in terms of correct staging. Accurate staging was obtained in 88% of patients utilizing the integrated PET-CT scan, 65% of patients utilizing visual correlation of PET and CT scans, 58% with CT scans alone and 40% with PET scans alone. (The New England Journal of Medicine).

Collected from: SNM.org, The New England Journal of Medicine, Radiology, University of Pittsburgh Cancer Institute.